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The dosage of mushrooms containing psilocybin depends on the psilocybin and psilocin content of the mushroom which can vary significantly between and within the same species but is typically around 0.5–2.0% of the dried weight of the mushroom. A typical low dose of the common species Psilocybe cubensis is about 1.0 to 2.5g while about 2.5 to 5.0 g dried mushroom material is considered a strong dose. Above 5 g is often considered a heavy dose with 5.0 grams of dried mushroom often being referred to as a “heroic dose”. The concentration of active psilocybin mushroom compounds varies from species to species, but also from mushroom to mushroom within a given species, subspecies or variety. The same holds true for different parts of the same mushroom. In the species, Psilocybe samuiensis, the dried cap of the mushroom contains the most psilocybin at about 0.23%–0.90%. The mycelium contains about 0.24%–0.32%. Magic mushrooms are hallucinogenic drugs, meaning they can cause you to see, hear, and feel sensations that seem real but are not. The effects of magic mushrooms, however, are highly variable and believed to be influenced by environmental factors. Shrooms have a long history of being associated with spiritual experiences and self-discovery. Many believe that naturally occurring drugs like magic mushrooms, weed, and mescaline are sacred herbs that enable people to attain superior spiritual states. Others take magic mushrooms to experience a sense of euphoria, connection, and a distorted sense of time
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The effects of psilocybin mushrooms come from psilocybin and psilocin. When psilocybin is ingested, it is broken down by the liver in a process called dephosphorylation. The resulting compound is called psilocin, which is responsible for the psychedelic effects. Psilocybin and psilocin create short-term increases in tolerance of users, thus making it difficult to abuse them because the more often they are taken within a short period of time, the weaker the resultant effects are. Psilocybin mushrooms have not been known to cause physical or psychological dependence (addiction)The psychedelic effects tend to appear around 20 minutes after ingestion and can last up to 6 hours. Physical effects including nausea, vomiting, euphoria, muscle weakness or relaxation, drowsiness, and lack of coordination may occur. As with many psychedelic substances, the effects of psychedelic mushrooms are subjective and can vary considerably among individual users. The mind-altering effects of psilocybin-containing mushrooms typically last from three to eight hours depending on dosage, preparation method, and personal metabolism. The first 3–4 hours after ingestion are typically referred to as the ‘peak’—in which the user experiences more vivid visuals and distortions in reality. The effects can seem to last much longer to the user because of psilocybin’s ability to alter time perceptioN.
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There are many myths about magic mushrooms. Some people believe, for example, that magic mushrooms are “safer” and produce a “milder” trip than other hallucinogenics. In fact, in addition to their potential to poison anyone who takes them, magic mushrooms are just as unpredictable in their effects as other drugs. Some people have reported much more intense and frightening hallucinations on magic mushrooms than on LSD. Many people also confuse fly agaric mushrooms with psilocybin-containing mushrooms—but they are not the same. Fly agaric mushrooms contain the psychoactive chemicals ibotenic acid and muscimol, which are known to cause twitching, drooling, sweating, dizziness, vomiting, and delirium. Like most drugs, the more you use magic mushrooms, the more tolerance you develop. Tolerance also develops quickly with regular use. This means that you need more of the drug to achieve the same effect. Developing a tolerance can be especially risky with shrooms because consuming a large amount can result in overdose symptoms, which while not fatal, can include agitation, vomiting, diarrhea, muscle weakness, panic or paranoia, psychosis, and seizures.
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